Metformin is the generic name of what is metformin 500 mg used for the prescription medications Glucophage, Glumetza, and Fortamet, used to control blood sugar in people with type what is metformin 500 mg used for 2 diabetes. Type 2 diabetes is a disease that occurs when the body does not produce or use insulin normally, which results in high blood sugar (glucose). Metformin works by decreasing the amount of sugar you absorb from food and reducing the amount of glucose your liver makes. It also increases your body's response metformin 1000 mg price to insulin. Metformin is in a class of medications called biguanides. It's sometimes used along with diet, exercise, and other medications to control blood glucose levels. It's also used to prevent the development of diabetes in people at high risk for the disease, treat metformin 1000 mg price polycystic ovary syndrome (pcos and control weight gain that occurs from taking certain drugs. The Food and Drug Administration apo metformin 500mg side effects (FDA) approved the medication in 1994. Metformin and pcos (Polycystic Ovary Syndrome). Polycystic ovary syndrome (pcos) is a common endocrine disorder that affects about one in 10 women of reproductive age. Women with pcos may have enlarged ovaries containing fluid, or follicles. These fluids may cause infrequent or prolonged menstrual periods, excess hair growth, acne, and weight gain. The exact cause of pcos is unknown, but the disorder has been linked to insulin resistance and excess insulin in the body. If you have insulin resistance, your body cannot use insulin effectively. As a result, your pancreas has to secrete more insulin to make glucose available to cells and tissues, including those that compose the ovaries. Researchers believe excess insulin may affect the ovaries by increasing androgen production, which may interfere with the ovaries' ability to ovulate. Because metformin ampk metformin can increase your bodys response to insulin, the drug has been used in the treatment of pcos, particularly in women with gestational diabetes. There is conflicting data surrounding the efficacy of metformin in pcos. Studies have reported that metformin can restore ovulation, reduce weight, reduce circulating androgen levels, reduce the risk of miscarriage, metformin ampk and reduce the risk of gestational diabetes mellitus in women with pcos. Its also been reported that metformin improves pregnancy outcome, as an adjunct to ovarian stimulation in women undergoing in vitro fertilization (IVF). However, there are other studies indicating that metformin is not effective in improving insulin response in women with pcos. Oral contraceptives are the first-choice therapy in most non-diabetic patients in pcos. Oral contraceptives are preferred over metformin for endometrial protection, hyperandrogenic symptoms, and restoration of normal menstrual cycles. If you have been diagnosed with pcos, talk to your doctor to see if metformin is an option. Metformin Warnings, in rare cases, metformin may cause a life-threatening condition known as lactic acidosis (a build-up of lactic acid in the body). You may be more likely to develop this condition if you: Have liver or kidney disease, have congestive heart failure. Have a severe infection, drink large amounts of alcohol, are dehydrated. You should tell your doctor if you are over 80 apo metformin 500mg side effects years old and if you have ever suffered a heart attack, stroke, diabetic ketoacidosis (an extremely high blood sugar episode metformin 1000 mg price that requires emergency medical treatment) or coma, or kidney, heart, or liver disease. You should also tell your doctor you are taking metformin before having any type of surgery, including dental procedures. If you are having any type. X-ray where dye is injected, you may need to stop taking metformin. Your apo metformin 500mg side effects doctor will advise you on when to stop and restart the drug. Some laboratory animals that were given high doses of metformin developed non-cancerous abnormal growths of tissue (polyps) on the uterus. It is not known if this medicine increases the risk of polyps in humans.
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Benefits of metformin weight loss
If youre managing type 2 diabetes with metformin (Glucophage you might benefits of metformin weight loss be well acquainted with unwanted side effects of this drug namely, upset stomach, diarrhea, muscle aches, and sleepiness. These can be a benefits of metformin weight loss figurative and literal pain, but you might welcome one side effect of metformin with open arms, particularly if youve struggled to lose weight. Metformin isnt a weight loss drug, but researchers have found a link between the drug and weight loss. In fact, a long-term study published in April 2012 in the journal. Diabetes Care that was conducted by the Diabetes Prevention Program (DPP) concluded that the drug could serve as a treatment for excess body weight, although more studies are needed. What Is, metformin and How Does It Work? Metformin has been considered a first-line medication in the treatment of type 2 diabetes, and it mainly acts by lowering the amount of glucose released by the liver, says. Minisha Sood, MD, an endocrinologist at Lenox Hill Hospital in New York City. It also helps a hormone called insulin to work benefits of metformin weight loss better by helping muscles use glucose in a more efficient manner. . When insulin works better (and insulin sensitivity improves a persons insulin levels are lower than they would be otherwise. Theres no cure for type 2 diabetes, but the right combination of medication and healthy lifestyle can stabilize blood sugar levels, which, of course, is the end goal of any diabetes treatment. As the medication helps your body properly metabolize food and restores your ability to respond to insulin, youll not only feel better, you can potentially avoid complications of high blood sugar, such as heart disease, kidney damage, nerve damage (diabetic neuropathy and eye damage (retinopathy). Why Does, metformin, cause, weight, loss? The relationship between metformin and weight is unclear, but several theories provide a plausible explanation for weight fluctuations. Reduced hunger is one proven side effect of metformin, according to the Mayo Clinic. It might not appear as if youre eating less with this drug, but the number of calories youre currently consuming for breakfast, lunch, and dinner might be lower than your normal food intake. This subtle change in appetite could be responsible for a gradual decline in weight. Having a frequent upset stomach or diarrhea, which is another side effect of the drug, can also affect your food intake. Temporary gastrointestinal upset (typically experienced at the beginning of treatment) from taking metformin may also play a role in weight loss, says Suzanne Magnotta, benefits of metformin weight loss RD, CDE, vice president of clinical services for Achieving Better Control in Conshohocken, Pennsylvania. Gastrointestinal symptoms common with this drug include stomach pain, diarrhea, and nausea. Discomfort can be so severe that you may not feel like eating much, and subsequently consume fewer calories. Is Long-Term Weight Loss Possible on Metformin? Even though metformin can help you shed pounds, the amount you lose might be far less than expected. On average, weight loss after one year on the drug is only 6 pounds, according to the April 2012 Diabetes Care study. So while metformin is often given to people with high insulin levels who have difficulty losing weight, its not a miracle weight loss solution, says.
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Why doctors in the know no longer prescribe metformin
Although the year is young, it has already brought my first moral dilemma. In early January a friend mentioned that his New Year's resolution was to why doctors in the know no longer prescribe metformin beat his chronic depression once and for all. Over the years he had tried a medicine chest's worth of antidepressants, but none had really helped in why doctors in the know no longer prescribe metformin any enduring way, and when the side effects became so unpleasant that he stopped taking them, the withdrawal symptoms (cramps, dizziness, headaches) were torture. Did I know of any research that might help him decide whether a new antidepressant his doctor recommended might finally lift his chronic darkness at noon? The moral dilemma was this: oh, yes, I knew of 20-plus years of research on antidepressants, from the old tricyclics to the newer selective serotonin reuptake inhibitors (ssris) that target serotonin (Zoloft, Paxil, and the granddaddy of them all, Prozac, as well as their generic. The research had shown why doctors in the know no longer prescribe metformin that antidepressants help about three quarters of people with depression who take them, a consistent finding that serves as the basis for the oft-repeated mantra "There is no question that the safety and efficacy of antidepressants rest on solid scientific evidence. The New York Times. But ever since a seminal study in 1998, whose findings were reinforced by landmark research. The Journal of the, american Medical Association last month, that evidence has come with a big asterisk. Yes, the drugs are effective, in that they lift depression in most patients. But that benefit is hardly more than what patients get when they, unknowingly and as part of a study, take a dummy pilla placebo. As more and more scientists who study depression and the drugs that treat it are concluding, that suggests that antidepressants are basically expensive Tic Tacs. Hence the moral dilemma. The placebo effectthat is, a medical benefit you get from an inert pill or other sham treatmentrests on the holy trinity of belief, expectation, and hope. But telling someone with depression who is being helped by antidepressants, or who (like my friend) hopes to be helped, threatens to topple the whole house of cards. Explain that it's all in their heads, that the reason they're benefiting is the same reason why Disney's Dumbo could initially fly only with a feather clutched in his trunkbelieving makes it soand the magic dissipates like fairy dust in a windstorm. So rather than tell my friend all this, I chickened out. Sure, I said, there's lots of research showing that a new kind of antidepressant might help you. Come, let me show you the studies on PubMed. It seems I am not alone in having moral qualms about blowing the whistle on antidepressants. That first analysis, in 1998, examined 38 manufacturer-sponsored studies involving just over 3,000 depressed patients. The authors, psychology researchers Irving Kirsch and Guy Sapirstein of the University of Connecticut, sawas everyone else hadthat patients did improve, often substantially, on ssris, tricyclics, and even MAO inhibitors, a class of antidepressants that dates from the 1950s. This improvement, demonstrated in scores of clinical trials, is the basis for the ubiquitous claim that antidepressants work. But when Kirsch compared the improvement in patients taking the drugs with the improvement in those taking dummy pillsclinical trials typically compare an experimental drug with a placebohe saw that the difference was minuscule. Patients on a placebo improved about 75 percent as much as those on drugs. Put another way, three quarters of the benefit from antidepressants seems to be a placebo effect. "We wondered, what's going on?" recalls Kirsch, who is now at the University of Hull in England. "These are supposed to be wonder drugs and have huge effects.". Recommended Slideshows, the study's impact? The number of Americans taking antidepressants doubled in a decade, from.3 million in 1996 to 27 million in 2005. To be sure, the drugs have helped tens of millions of people, and Kirsch certainly does not advocate that patients suffering from depression stop taking the drugs. But they are not necessarily the best first choice. Psychotherapy, for instance, works for moderate, severe, and even very severe depression. And why doctors in the know no longer prescribe metformin although for some patients, psychotherapy in combination with an initial course of prescription antidepressants works even better, the question is, how do the drugs work? Kirsch's study and, now, others conclude that the lion's share of the drugs' effect comes from the fact that patients expect to be helped by them, and not from any direct chemical action on the brain, especially for anything short of very severe depression. As the inexorable rise in the use of antidepressants suggests, that conclusion can't hold a candle to the simplistic "antidepressants work!" (unstated corollary: "but don't ask how message.